DADA2 project

Deficiency of Adenosine Deaminase 2 (DADA2) is a rare genetic immune disorder that can lead to recurrent fevers, strokes, and inflammation of blood vessels, often starting in childhood.

We study the molecular mechanism of ADA2 in immune cells, with a particular focus on its role in nucleic-acid sensing. To address this, we combine cellular and molecular biology approaches with ex-vivo experimental immunology. In addition, we perform transcriptomic profiling at both bulk and single-cell resolution to map how ADA2 shapes intra- and intercellular networks, enabling us to understand the impact of ADA2 deficiency at a systems level.