Microbiota & Vaccination project

Vaccination in early life often shows limited efficacy, while growing evidence suggests that the microbiota plays a key role in shaping immune development during this critical period. Most human studies in this field, however, remain largely correlational. Our research investigates how the microbiota around birth influence the immune response to Influenza A virus (IAV) vaccination, with a particular focus on the cells and pathways driving the germinal center reaction.